The Endogenous Brain Constituent N-Arachidonoyl l-Serine Is an Activator of Large Conductance Ca(2+)-Activated K(+) Channels

The novel endocannabinoid-like lipid N-arachidonoyl l-serine (ARA-S) causes vasodilation through both endothelium-dependent and -independent mechanisms. We have analyzed the vasorelaxant effect of ARA-S in isolated vascular preparations and its effects on Ca(2+)-activated K(+) currents in human embr...

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Hlavní autoři: Godlewski, Grzegorz, Offertáler, László, Osei-Hyiaman, Douglas, Mo, Fong Ming, Harvey-White, Judith, Liu, Jie, Davis, Margaret I., Zhang, Li, Razdan, Raj K., Milman, Garry, Pacher, Pal, Mukhopadhyay, Partha, Lovinger, David M., Kunos, George
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Pharmacology and Experimental Therapeutics 2009
Témata:
Cardiovascular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605781/
https://ncbi.nlm.nih.gov/pubmed/18923087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.144717
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