Secreted Proteoglycans Directly Mediate Human Embryonic Stem Cell-FGF2 Interactions Critical for Proliferation

Human embryonic stem (ES) cells can be maintained in an undifferentiated state if the culture medium is first conditioned on a layer of mouse embryonic fibroblast (MEF) feeder cells. Here we show that human ES cell proliferation is coordinated by MEF-secreted heparan sulfate proteoglycans (HSPG) in...

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Bibliografski detalji
Glavni autori: Levenstein, Mark E., Berggren, W. Travis, Lee, Ji Eun, Conard, Kevin R., Llanas, Rachel A., Wagner, Ryan J., Smith, Lloyd M., Thomson, James A.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605780/
https://ncbi.nlm.nih.gov/pubmed/18802039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/stemcells.2007-1056
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