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Phospholipase Cβ3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain

Treatment of neuropathic pain is a major clinical problem. This study shows expression of phospholipase ß3 (PLCß3) in mouse and human DRG neurons, mainly in small ones and mostly with a nonpeptidergic phenotype. After spared nerve injury, the pain threshold was strongly reduced, and systemic treatme...

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Detalhes bibliográficos
Main Authors: Shi, Tie-Jun Sten, Liu, Su-Xing Leslie, Hammarberg, Henrik, Watanabe, Masahiko, Xu, Zhi-Qing David, Hökfelt, Tomas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604939/
https://ncbi.nlm.nih.gov/pubmed/19066214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810899105
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