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Potential role of purinergic signaling in urinary concentration in inner medulla: insights from P2Y2 receptor gene knockout mice

Osmotic reabsorption of water through aquaporin-2 (AQP2) in the inner medulla is largely dependent on the urea concentration gradients generated by urea transporter (UT) isoforms. Vasopressin (AVP) increases expression of both AQP2 and UT-A isoforms. Activation of the P2Y2 receptor (P2Y2-R) in the m...

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Autors principals: Zhang, Yue, Sands, Jeff M., Kohan, Donald E., Nelson, Raoul D., Martin, Christopher F., Carlson, Noel G., Kamerath, Craig D., Ge, Yuqiang, Klein, Janet D., Kishore, Bellamkonda K.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604830/
https://ncbi.nlm.nih.gov/pubmed/18829742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90311.2008
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