Ablation of developing podocytes disrupts cellular interactions and nephrogenesis both inside and outside the glomerulus

Podocyte loss in adults leads to glomerulosclerosis. However, the impact of podocyte loss on glomerulogenesis and the development of the kidney as a whole has not been directly studied. Here, we used a podocyte-specific Cre transgene to direct the production of diphtheria toxin (DTA) inside podocyte...

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Main Authors: Jia, Qunshan, McDill, Bradley W., Sankarapandian, Bala, Wu, Sen, Liapis, Helen, Holzman, Lawrence B., Capecchi, Mario R., Miner, Jeffrey H., Chen, Feng
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604822/
https://ncbi.nlm.nih.gov/pubmed/18842818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90519.2008
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