Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice

High tidal volume (HV(T)) ventilation causes pulmonary endothelial barrier dysfunction. HV(T) ventilation also increases lung nitric oxide (NO) and cGMP. NO contributes to HV(T) lung injury, but the role of cGMP is unknown. In the current study, ventilation of isolated C57BL/6 mouse lungs increased...

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Autori principali: Schmidt, Eric P., Damarla, Mahendra, Rentsendorj, Otgonchimeg, Servinsky, Laura E., Zhu, Bing, Moldobaeva, Aigul, Gonzalez, Alfredo, Hassoun, Paul M., Pearse, David B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2008
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604795/
https://ncbi.nlm.nih.gov/pubmed/18849438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90329.2008
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