The Wallerian degeneration slow (Wld(s)) gene does not attenuate disease in a mouse model of spinal muscular atrophy

Spinal Muscular Atrophy (SMA) is a severe neuromuscular disease characterized by loss of spinal α-motor neurons, resulting in the paralysis of skeletal muscle. SMA is caused by deficiency of Survival Motor Neuron (SMN) protein levels. Recent evidence has highlighted an axon-specific role for SMN pro...

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Detalhes bibliográficos
Main Authors: Rose, Ferrill F., Meehan, Philip W., Coady, Tristan H., Garcia, Virginia B., Garcia, Michael L., Lorson, Christian L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603628/
https://ncbi.nlm.nih.gov/pubmed/18680723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.07.130
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