Gamma-Secretase-Dependent and -Independent Effects of Presenilin1 on β-Catenin·Tcf-4 Transcriptional Activity

Presenilin1 (PS1) is a component of the γ-secretase complex mutated in cases of Familial Alzheimer's disease (FAD). PS1 is synthesized as a 50 kDa peptide subsequently processed to two 29 and 20 kDa subunits that remain associated. Processing of PS1 is inhibited by several mutations detected in...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Raurell, Imma, Codina, Montserrat, Casagolda, David, del Valle, Beatriz, Baulida, Josep, de Herreros, Antonio García, Duñach, Mireia
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2008
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603589/
https://ncbi.nlm.nih.gov/pubmed/19114997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004080
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים