25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway

The oxysterol receptor LXR is a key transcriptional regulator of lipid metabolism. LXR increases expression of SREBP-1, which in turn regulates at least 32 genes involved in lipid synthesis and transport. We recently identified 25-hydroxycholesterol-3-sulfate (25HC3S) as an important regulatory mole...

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Huvudupphovsmän: Ma, Yongjie, Xu, Leyuan, Rodriguez-Agudo, Daniel, Li, Xiaobo, Heuman, Douglas M., Hylemon, Phillip B., Pandak, William M., Ren, Shunlin
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2008
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603552/
https://ncbi.nlm.nih.gov/pubmed/18854425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.90555.2008
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