Blm10 binds to pre-activated proteasome core particles with open gate conformation

Blm10, a crucial protease of eukaryotic cells, is bound to yeast proteasome core particles (CPs). Two gates, at both ends of the CP, control the access of protein substrates to the catalytic cavity of the CP. Normally, substrate access is auto-inhibited by a closed gate conformation unless regulator...

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Bibliographic Details
Main Authors: Lehmann, Andrea, Jechow, Katharina, Enenkel, Cordula
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2008
Subjects:
Scientific Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603454/
https://ncbi.nlm.nih.gov/pubmed/18927584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.190
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