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In C. elegans, High Levels of dsRNA Allow RNAi in the Absence of RDE-4
C. elegans Dicer requires an accessory double-stranded RNA binding protein, RDE-4, to enact the first step of RNA interference, the cleavage of dsRNA to produce siRNA. While RDE-4 is typically essential for RNAi, we report that in the presence of high concentrations of trigger dsRNA, rde-4 deficient...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2603325/ https://ncbi.nlm.nih.gov/pubmed/19112503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004052 |
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