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AIR POLLUTION INDUCES ENHANCED MITOCHONDRIAL OXIDATIVE STRESS IN CYSTIC FIBROSIS AIRWAY EPITHELIUM
We studied the effects of airborne particulates (PM) on Cystic Fibrosis (CF) epithelium. We noted that PM enhanced human CF bronchial epithelial apoptosis, activated caspase-9 and PARP-1; and reduced mitochondrial membrane potential. Mitochondrial inhibitors (DIDS, Rotenone and TTFA) blocked PM-indu...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2603298/ https://ncbi.nlm.nih.gov/pubmed/18817777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2008.09.030 |
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