Depletion of Intestinal Phosphate following Surgical Injury Activates the Virulence of P. aeruginosa causing Lethal Gut-Derived Sepsis

BACKGROUND: Here we explored the possibility that the opportunistic pathogen, Pseudomonas aeruginosa (P.a) senses low phosphate (Pi) as a signal of host injury and shifts to a lethal phenotype. METHODS: Virulence expression in P. aeruginosa was examined in vitro under low phosphate conditions by ass...

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Bibliographic Details
Main Authors: Long, Jason, Zaborina, Olga, Holbrook, Christopher, Zaborin, Alexander, Alverdy, John
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2601706/
https://ncbi.nlm.nih.gov/pubmed/18656625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2008.03.045
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