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A function for IL-7R for CD4(+)CD25(+) Foxp3(+) T regulatory cells

The IL-2/IL-2R interaction is important for development and peripheral homeostasis of T regulatory (T(reg)) cells. IL-2- and IL-2R-deficient mice are not completely devoid of Foxp3(+) cells, but rather lack population of mature CD4(+)CD25(+)Foxp3(high) T(reg) cells and contain few immature CD4(+)CD2...

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Bibliografiske detaljer
Main Authors: Bayer, Allison L., Lee, Joon Youb, de la Barrera, Anabel, Surh, Charles D., Malek, Thomas R.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2601574/
https://ncbi.nlm.nih.gov/pubmed/18566388
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