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Clonal Interference, Multiple Mutations and Adaptation in Large Asexual Populations

Two important problems affect the ability of asexual populations to accumulate beneficial mutations and hence to adapt. First, clonal interference causes some beneficial mutations to be outcompeted by more-fit mutations that occur in the same genetic background. Second, multiple mutations occur in s...

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Detalhes bibliográficos
Main Authors: Fogle, Craig A., Nagle, James L., Desai, Michael M.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600949/
https://ncbi.nlm.nih.gov/pubmed/18832359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.090019
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