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Clonal Interference, Multiple Mutations and Adaptation in Large Asexual Populations

Two important problems affect the ability of asexual populations to accumulate beneficial mutations and hence to adapt. First, clonal interference causes some beneficial mutations to be outcompeted by more-fit mutations that occur in the same genetic background. Second, multiple mutations occur in s...

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Detalles Bibliográficos
Main Authors: Fogle, Craig A., Nagle, James L., Desai, Michael M.
Formato: Artigo
Idioma:Inglês
Publicado: Genetics Society of America 2008
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600949/
https://ncbi.nlm.nih.gov/pubmed/18832359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.090019
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