Coprinus cinereus rad50 Mutants Reveal an Essential Structural Role for Rad50 in Axial Element and Synaptonemal Complex Formation, Homolog Pairing and Meiotic Recombination

The Mre11/Rad50/Nbs1 (MRN) complex is required for eukaryotic DNA double-strand break (DSB) repair and meiotic recombination. We cloned the Coprinus cinereus rad50 gene and showed that it corresponds to the complementation group previously named rad12, identified mutations in 15 rad50 alleles, and m...

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Päätekijät: Acharya, Sonia N., Many, Alexander M., Schroeder, Andrew P., Kennedy, Felicia M., Savytskyy, Oleksandr P., Grubb, Jennifer T., Vincent, Jack A., Friedle, Elizabeth A., Celerin, Martina, Maillet, Daniel S., Palmerini, Heather J., Greischar, Megan A., Moncalian, Gabriel, Williams, R. Scott, Tainer, John A., Zolan, Miriam E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Genetics Society of America 2008
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Investigations
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600930/
https://ncbi.nlm.nih.gov/pubmed/18940790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.092775
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