Atheroprotective Effects of Methotrexate on Reverse Cholesterol Transport Proteins and Foam Cell Transformation in THP-1 Human Monocytes/Macrophages

OBJECTIVE: To determine whether MTX can overcome the atherogenic effect of COX-2 inhibitors and IFN-γ, both of which suppress cholesterol efflux protein levels and promote foam cell transformation in THP-1 human monocytes/macrophages. METHODS: Message and protein level of the reverse cholesterol tra...

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Autores principales: Reiss, Allison B., Carsons, Steven E., Anwar, Kamran, Rao, Soumya, Edelman, Sari D., Zhang, Hongwei, Fernandez, Patricia, Cronstein, Bruce N., Chan, Edwin S.L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2599810/
https://ncbi.nlm.nih.gov/pubmed/19035488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24040
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