Inducing Cross-Clade Neutralizing Antibodies against HIV-1 by Immunofocusing

BACKGROUND: Although vaccines are important in preventing viral infections by inducing neutralizing antibodies (nAbs), HIV-1 has proven to be a difficult target and escapes humoral immunity through various mechanisms. We sought to test whether HIV-1 Env mimics may serve as immunogens. METHODOLOGY/PR...

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Main Authors: Humbert, Michael, Rasmussen, Robert A., Ong, Helena, Kaiser, Fabian M. P., Hu, Shiu-Lok, Ruprecht, Ruth M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597739/
https://ncbi.nlm.nih.gov/pubmed/19081789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003937
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