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Effect of Site-directed Mutagenesis of Methylglyoxal- Modifiable Arginine Residues on the Structure and Chaperone Function of Human αA-crystallin
We reported previously that chemical modification of human αA-crystallin by a metabolic dicarbonyl compound, methylglyoxal (MGO), enhances its chaperone-like function, a phenomenon which we attributed to formation of argpyrimidine at arginine residues (R) 21, 49 and 103. This structural change remov...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597574/ https://ncbi.nlm.nih.gov/pubmed/16584192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi052574s |
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