Toll-Like Receptor-4 Mediates Neuronal Apoptosis Induced by Amyloid β-Peptide and the Membrane Lipid Peroxidation Product 4-Hydroxynonenal

The innate immune system senses the invasion of pathogenic microorganisms and tissue injury through Toll-like receptors (TLR), a mechanism thought to be limited to immune cells. We recently found that neurons express several TLRs, and that the levels of TLR2 and TLR4 are increased in neurons in resp...

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Main Authors: Tang, Sung-Chun, Lathia, Justin D., Selvaraj, Pradeep K., Jo, Dong-Gyu, Mughal, Mohamed R., Cheng, Aiwu, Siler, Dominic A., Markesbery, William R., Arumugam, Thiruma V., Mattson, Mark. P.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597513/
https://ncbi.nlm.nih.gov/pubmed/18586243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2008.05.014
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