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Comprehensive in silico mutagenesis highlights functionally important residues in proteins
Motivation: Mutating residues into alanine (alanine scanning) is one of the fastest experimental means of probing hypotheses about protein function. Alanine scans can reveal functional hot spots, i.e. residues that alter function upon mutation. In vitro mutagenesis is cumbersome and costly: probing...
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| Huvudupphovsmän: | , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Oxford University Press
2008
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597370/ https://ncbi.nlm.nih.gov/pubmed/18689826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btn268 |
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