Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally

TEL-AML1 (ETV6-RUNX1) is the most common translocation in the childhood leukemias, and is a prenatal mutation in most children. This translocation has been detected at a high rate among newborns (∼1%); therefore the rate-limiting event for leukemia appears to be secondary mutations. A frequent such...

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Autors principals: Wiemels, Joseph L., Hofmann, Jerry, Kang, Michelle, Selzer, Rebecca, Green, Roland, Zhou, Mi, Zhong, Sheng, Zhang, Luoping, Smith, Martyn T., Marsit, Carmen, Loh, Mignon, Buffler, Patricia, Yeh, Ru-Fang
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597307/
https://ncbi.nlm.nih.gov/pubmed/19047175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2139
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