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Role of Shiga toxin in the pathogenesis of bacillary dysentery, studied by using a Tox- mutant of Shigella dysenteriae 1.

A Tox- mutant of Shigella dysenteriae 1, SC501, was genetically engineered by cloning the Shiga toxin operon, inserting a cassette into the A subunit gene, and exchanging this in vitro-mutagenized sequence with the wild-type gene. SC501 produced a low amount of residual cytotoxicity which was not ne...

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发表在:Infect Immun
Principais autores: Fontaine, A, Arondel, J, Sansonetti, P J
格式: Artigo
语言:Inglês
出版: American Society for Microbiology (ASM) 1988
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在线阅读:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC259708/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3053452/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.56.12.3099-3109.1988
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