Deciphering the Ligand-binding Sites in the Borrelia burgdorferi Complement Regulator-acquiring Surface Protein 2 Required for Interactions with the Human Immune Regulators Factor H and Factor H-like Protein 1

Borrelia burgdorferi, the etiologic agent of Lyme disease, employs sophisticated means to evade killing by its mammalian hosts. One important immune escape mechanism is the inhibition of complement activation mediated by interactions of the host-derived immune regulators factor H (CFH) and factor H-...

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Hlavní autoři: Siegel, Corinna, Schreiber, Johanna, Haupt, Katrin, Skerka, Christine, Brade, Volker, Simon, Markus M., Stevenson, Brian, Wallich, Reinhard, Zipfel, Peter F., Kraiczy, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596382/
https://ncbi.nlm.nih.gov/pubmed/18824548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805844200
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