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Role for perinuclear chromosome tethering in maintenance of genome stability

Repetitive DNA sequences, which constitute half the genome in some organisms, often undergo homologous recombination. This can instigate genomic instability due to gain or loss of DNA1. Assembly of DNA into silent chromatin is generally thought to serve as a mechanism ensuring repeat stability by li...

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Detalhes bibliográficos
Main Authors: Mekhail, Karim, Seebacher, Jan, Gygi, Steven P., Moazed, Danesh
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596277/
https://ncbi.nlm.nih.gov/pubmed/18997772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07460
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