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Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy
To study effects of mitochondria complex I (CI, NADH:ubiquinone oxidoreductase) deficiency, we inactivated the Ndufs4 gene (KO mice), which encodes an 18 kD subunit of the 45-protein complex. Although small, KO mice appeared healthy until ~5 wk of age, when ataxic signs began and progressed until de...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2593686/ https://ncbi.nlm.nih.gov/pubmed/18396137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.02.004 |
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