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Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma
Infantile hemangiomas are localized and rapidly growing regions of disorganized angiogenesis. We demonstrate that expression of VEGFR1 in hemangioma endothelial cells (hemEC) and tissue is only 10−20% of that in controls. Low VEGFR1 levels result in VEGF-dependent activation of VEGFR2 and downstream...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2593632/ https://ncbi.nlm.nih.gov/pubmed/18931684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1877 |
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