Failure of Terminal Erythroid Differentiation in EKLF-Deficient Mice Is Associated with Cell Cycle Perturbation and Reduced Expression of E2F2

Erythroid Krüppel-like factor (EKLF) is a Krüppel-like transcription factor identified as a transcriptional activator and chromatin modifier in erythroid cells. EKLF-deficient (Eklf(−/−)) mice die at day 14.5 of gestation from severe anemia. In this study, we demonstrate that early progenitor cells...

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Autors principals: Pilon, Andre M., Arcasoy, Murat O., Dressman, Holly K., Vayda, Serena E., Maksimova, Yelena D., Sangerman, Jose I., Gallagher, Patrick G., Bodine, David M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593440/
https://ncbi.nlm.nih.gov/pubmed/18852285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01087-08
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