Alanylclavam Biosynthetic Genes Are Clustered Together with One Group of Clavulanic Acid Biosynthetic Genes in Streptomyces clavuligerus

Streptomyces clavuligerus produces at least five different clavam metabolites, including clavulanic acid and the methionine antimetabolite, alanylclavam. In vitro transposon mutagenesis was used to analyze a 13-kb region upstream of the known paralogue gene cluster. The paralogue cluster includes on...

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Bibliographic Details
Main Authors: Zelyas, Nathan J., Cai, Hui, Kwong, Thomas, Jensen, Susan E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Genetics and Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593231/
https://ncbi.nlm.nih.gov/pubmed/18931110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00698-08
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