Cytokine blockade attenuates sympathoexcitation in heart failure: cross-talk between nNOS, AT-1R and cytokines in the hypothalamic paraventricular nucleus

OBJECTIVE: To investigate evidence for the interplay between cytokines, angiotensin II and nNOS in the paraventricular nucleus (PVN), for regulating sympathetic outflow in a rat model of CHF. METHODS AND RESULTS: Heart failure was induced in Sprague-Dawley rats by coronary artery ligation. One group...

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Main Authors: Guggilam, Anuradha, Patel, Kaushik P, Haque, Masudul, Ebenezer, Philip J, Kapusta, Daniel R, Francis, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593148/
https://ncbi.nlm.nih.gov/pubmed/18550427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejheart.2008.05.004
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