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Secretion of Insulinotropic Proteins by Commensal Bacteria: Rewiring the Gut To Treat Diabetes

Here, we show that commensal bacteria can stimulate intestinal epithelial cells to secrete insulin in response to glucose. Commensal strains were engineered to secrete the insulinotropic proteins GLP-1 and PDX-1. Epithelia stimulated by engineered strains and glucose secreted up to 1 ng ml(−1) of in...

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Detalhes bibliográficos
Main Authors: Duan, Faping, Curtis, Katherine L., March, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592943/
https://ncbi.nlm.nih.gov/pubmed/18836005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01019-08
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