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Secretion of Insulinotropic Proteins by Commensal Bacteria: Rewiring the Gut To Treat Diabetes

Here, we show that commensal bacteria can stimulate intestinal epithelial cells to secrete insulin in response to glucose. Commensal strains were engineered to secrete the insulinotropic proteins GLP-1 and PDX-1. Epithelia stimulated by engineered strains and glucose secreted up to 1 ng ml(−1) of in...

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Bibliografische gegevens
Hoofdauteurs: Duan, Faping, Curtis, Katherine L., March, John C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2008
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592943/
https://ncbi.nlm.nih.gov/pubmed/18836005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01019-08
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