Selective Removal of Aberrant Extender Units by a Type II Thioesterase for Efficient FR-008/Candicidin Biosynthesis in Streptomyces sp. Strain FR-008

Gene fscTE, encoding a putative type II thioesterase (TEII), was associated with the FR-008/candicidin gene cluster. Deletion of fscTE reduced approximately 90% of the FR-008/candicidin production, while the production level was well restored when fscTE was added back to the mutant in trans. FscTE w...

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Detalhes bibliográficos
Main Authors: Zhou, Yongjun, Meng, Qingqing, You, Delin, Li, Jialiang, Chen, Shi, Ding, Dazhong, Zhou, Xiufen, Zhou, Huchen, Bai, Linquan, Deng, Zixin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Genetics and Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592917/
https://ncbi.nlm.nih.gov/pubmed/18836004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01012-08
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