Different Effects of Angiotensin Converting Enzyme Inhibitors on Endothelin-1 and Nitric Oxide Balance in Human Vascular Endothelial Cells: Evidence of an Oxidant-Sensitive Pathway

Angiotensin converting enzyme inhibitors (ACE-I) are able to reduce the formation of the potent vasoconstrictor endothelin-1 and increase nitric oxide bioavailability in human vascular endothelial cells (HUVECs). We tested the effects of two sulfhydryl-containing ACE-I, zofenoprilat, and captopril,...

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Bibliographic Details
Main Authors: Desideri, Giovambattista, Grassi, Davide, Croce, Giuseppe, Bocale, Raffaella, Tiberti, Sergio, Evangelista, Stefano, Necozione, Stefano, Di Orio, Ferdinando, Ferri, Claudio
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592601/
https://ncbi.nlm.nih.gov/pubmed/19079593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2008/305087
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