Upregulation of insulin receptor substrate-2 in pancreatic β cells prevents diabetes

The insulin receptor substrate-2 (Irs2) branch of the insulin/IGF signaling system coordinates peripheral insulin action and pancreatic β cell function, so mice lacking Irs2 display similarities to humans with type 2 diabetes. Here we show that β cell–specific expression of Irs2 at a low or a high l...

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Hauptverfasser: Hennige, Anita M., Burks, Deborah J., Ozcan, Umut, Kulkarni, Rohit N., Ye, Jing, Park, Sunmin, Schubert, Markus, Fisher, Tracey L., Dow, Matt A., Leshan, Rebecca, Zakaria, Mark, Mossa-Basha, Mahmud, White, Morris F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC259126/
https://ncbi.nlm.nih.gov/pubmed/14617753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318581
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