Mechanism of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-mediated mitochondrial dysfunction in rat liver

Despite numerous reports citing the acute hepatotoxicity caused by MDMA (3,4-methylenedioxymethamphetamine, ecstasy), the underlying mechanism of organ damage is poorly understood. We hypothesized that key mitochondrial proteins are oxidatively-modified and inactivated in MDMA-exposed tissues. The a...

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Main Authors: Moon, Kwan-Hoon, Upreti, Vijay V., Yu, Li-Rong, Lee, Insong J., Ye, Xiaoying, Eddington, Natalie D., Veenstra, Timothy D., Song, Byoung-Joon
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590641/
https://ncbi.nlm.nih.gov/pubmed/18780394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.200800215
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