Early-life exposure to endotoxin alters hypothalamic–pituitary–adrenal function and predisposition to inflammation

We have investigated whether exposure to Gram-negative bacterial endotoxin in early neonatal life can alter neuroendocrine and immune regulation in adult animals. Exposure of neonatal rats to a low dose of endotoxin resulted in long-term changes in hypothalamic–pituitary–adrenal (HPA) axis activity,...

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Hauptverfasser: Shanks, Nola, Windle, Richard J., Perks, Paula A., Harbuz, Michael S., Jessop, David S., Ingram, Colin D., Lightman, Stafford L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2000
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC25882/
https://ncbi.nlm.nih.gov/pubmed/10779563
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