Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contraction and results in postnatal death in mice

The physiological relevance of smooth muscle myosin isoforms SM1 and SM2 has not been understood. In this study we generated a mouse model specifically deficient in SM2 myosin isoform but expressing SM1, using an exon-specific gene targeting strategy. The SM2 homozygous knockout (SM2(−/−)) mice died...

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Bibliographic Details
Main Authors: Chi, Mei, Zhou, Yingbi, Vedamoorthyrao, Srikanth, Babu, Gopal J., Periasamy, Muthu
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587533/
https://ncbi.nlm.nih.gov/pubmed/19011095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808162105
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