CHANGES IN APICAL DENDRITIC STRUCTURE CORRELATE WITH SUSTAINED ERK1/2 PHOSPHORYLATION IN MEDIAL PREFRONTAL CORTEX OF A RAT MODEL OF DOPAMINE D(1) RECEPTOR AGONIST SENSITIZATION

Rats lesioned with 6-hydroxydopamine (6-OHDA) as neonates exhibit behavioral and neurochemical abnormalities in adulthood that mimic Lesch-Nyhan disease, schizophrenia and other developmental disorders of frontostriatal circuit dysfunction. In these animals, a latent sensitivity to D(1) agonists is...

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Detalhes bibliográficos
Main Authors: Papadeas, Sophia T., Halloran, Christopher, McCown, Thomas J., Breese, George R., Blake, Bonita L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587500/
https://ncbi.nlm.nih.gov/pubmed/18785628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cne.21835
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