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Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26
Mdm2 regulates the p53 tumor suppressor by promoting its proteasome-mediated degradation. Mdm2 and p53 engage in an autoregulatory feedback loop that maintains low p53 activity in non-stressed cells. We now report that Mdm2 regulates p53 levels also by targeting ribosomal protein L26. L26 binds p53...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587494/ https://ncbi.nlm.nih.gov/pubmed/18951086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.08.031 |
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