Targeting the Aggresome Pathway in Hematologic Malignancies

Misfolded or unfolded proteins are often refolded with the help of chaperones or degraded by the 26S proteasome. An alternative fate of these proteins is the aggresome pathway. The microtubule-organizing center (MTOC) transports unfolded proteins to lysosomes and are degraded through autophagy. Hist...

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Main Authors: Simms-Waldrip, Tiffany, Rodriguez-Gonzalez, Agustin, Lin, Tara, Ikeda, Alan K, Fu, Cecilia, Sakamoto, Kathleen M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587432/
https://ncbi.nlm.nih.gov/pubmed/18472289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2008.03.012
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