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Memory-like CD8(+) and CD4(+) T cells cooperate to break peripheral tolerance under lymphopenic conditions
The onset of autoimmunity in experimental rodent models and patients frequently correlates with a lymphopenic state. In this condition, the immune system has evolved compensatory homeostatic mechanisms that induce quiescent naive T cells to proliferate and differentiate into memory-like lymphocytes...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587230/ https://ncbi.nlm.nih.gov/pubmed/19033460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807743105 |
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