Diminished immunogenicity of a recombination-deficient derivative of Vibrio cholerae vaccine strain CVD103.

To address potential concerns over the release of genetically engineered live bacterial vaccines, we constructed a recombination-deficient derivative of the Vibrio cholerae O1 vaccine strain CVD103 (CVD103RM). Oral immunization of adult volunteers with CVD103RM showed that the recA mutation signific...

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Bibliografiske detaljer
Udgivet i:Infect Immun
Main Authors: Ketley, J M, Kaper, J B, Herrington, D A, Losonsky, G, Levine, M M
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC258653/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2323828/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.58.5.1481-1484.1990
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