IL-7 specifies B cell fate at the CLP to pre-proB transition stage by maintaining EBF expression

Interleukin 7 (IL-7) plays a critical role in B cell fate decision by regulating early B cell factor (EBF) expression. However, it was not clear when IL-7 stimulation is necessary in hemato/lymphopoiesis in adult mice. Here we show that pre-proB cells derived from IL-7(−/−) mice have lost B cell pot...

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Bibliographic Details
Main Authors: Kikuchi, Kazu, Kasai, Hirotake, Watanabe, Akiko, Lai, Anne Y., Kondo, Motonari
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586338/
https://ncbi.nlm.nih.gov/pubmed/18566404
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