Oral vaccination of mice against tetanus by use of a live attenuated Salmonella carrier.

A Salmonella typhimurium aroA mutant has been used as a live carrier to immunize mice against tetanus. Plasmid pTETtac4, which expresses a 50-kilodalton fragment of tetanus toxin (fragment C) under the control of the tac promoter, was introduced into SL3261 aroA. When used as a live vaccine and admi...

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Autors principals: Fairweather, N F, Chatfield, S N, Makoff, A J, Strugnell, R A, Bester, J, Maskell, D J, Dougan, G
Format: Artigo
Idioma:Inglês
Publicat: 1990
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC258627/
https://ncbi.nlm.nih.gov/pubmed/2182542
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