Construction of a urease-negative mutant of Proteus mirabilis: analysis of virulence in a mouse model of ascending urinary tract infection.

Proteus mirabilis, a urease-producing uropathogen, causes serious urinary tract infections in humans. To specifically evaluate the contribution of urease to virulence, a mutation was introduced into P. mirabilis HI4320 by homologous recombination. Virulence was assessed in the CBA mouse model of asc...

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Publicat a:Infect Immun
Autors principals: Jones, B D, Lockatell, C V, Johnson, D E, Warren, J W, Mobley, H L
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 1990
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC258592/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2180821/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.58.4.1120-1123.1990
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