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Identification of Channel-lining Amino Acid Residues in the Hydrophobic Segment of Colicin Ia

Colicin Ia is a bactericidal protein of 626 amino acid residues that kills its target cell by forming a channel in the inner membrane; it can also form voltage-dependent channels in planar lipid bilayer membranes. The channel-forming activity resides in the carboxy-terminal domain of ∼177 residues....

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Detalhes bibliográficos
Main Authors: Kienker, Paul K., Jakes, Karen S., Finkelstein, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585860/
https://ncbi.nlm.nih.gov/pubmed/19029376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200810042
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