Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

Neuritic plaques in the brains are one of the pathological hallmarks of Alzheimer's disease (AD). Amyloid β-protein (Aβ), the central component of neuritic plaques, is derived from β-amyloid precursor protein (APP) after β- and γ-secretase cleavage. The molecular mechanism underlying the pathog...

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Main Authors: Qing, Hong, He, Guiqiong, Ly, Philip T. T., Fox, Christopher J., Staufenbiel, Matthias, Cai, Fang, Zhang, Zhuohua, Wei, Shengcai, Sun, Xiulian, Chen, Chia-Hsiung, Zhou, Weihui, Wang, Ke, Song, Weihong
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585842/
https://ncbi.nlm.nih.gov/pubmed/18955571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081588
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