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Kinase domain mutants of Bcr enhance Bcr-Abl oncogenic effects
Bcr-Abl acquires its transforming abilitythro ugh its upregulated Abl tyrosine kinase activity. Bcr is a phosphoprotein with a novel serine/threonine kinase activitye ncoded by its first exon. In chronic myelogenous leukemia (CML) cells, Bcr-Abl phosphorylates Bcr on tyrosine residues reducing its k...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2585769/ https://ncbi.nlm.nih.gov/pubmed/17934518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1210851 |
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