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Pro-oxidant shift in glutathione redox state during aging
The GSH:GSSG ratio, which is the primary determinant of the cellular redox state, becomes progressively more pro-oxidizing during the aging process due to an elevation in the GSSG content and a decline in the ability for de novo GSH biosynthesis. The K(m) of glutamate-cysteine ligase (GCL), the rate...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2585506/ https://ncbi.nlm.nih.gov/pubmed/18652861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2008.06.001 |
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