Association of Arachidonate 12 Lipoxygenase Genotype Variation and Glycemic Control With Albuminuria in Type 2 Diabetes

BACKGROUND: Glycemic exposure activates 12-lipoxygenase (12LO) expression and formation of arachidonic acid-derived products. These products can induce cell hypertrophy, cell proliferation and extracellular matrix deposition, potentially leading to diabetic nephropathy (DN). STUDY DESIGN: cross-sect...

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Main Authors: Liu, Yongmei, Freedman, Barry I., Burdon, Kathryn P., Langefeld, Carl D., Howard, Timothy, Herrington, David, Goff, David C., Bowden, Donald W., Wagenknecht, Lynne E., Hedrick, Catherine C., Rich, Stephen S.
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585503/
https://ncbi.nlm.nih.gov/pubmed/18640486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.ajkd.2007.12.033
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